for veterinary use only with a prescription
Provet Oxytocin injection for Horses, cattle, sheep, goats, cats, and dogs it is used for the treatment of dystocia in animals,& agalactia let’s know more about the product
COMPOSITION:
Each ml Provet Oxytocin contains
10 IU Oxytocin
Pharmacological Properties:
Oxytocin is a cyclic non peptide hormone that has stimulant effects on the smooth muscle of the uterus and on the mammary gland.
It stimulates uterine motility increasing contraction and tone.
The induction of parturition, promotion of uterine involution after parturition, aid to the passage of retained placenta, and control of postpartum hemorrhage are consequences of uterine contraction.
It also stimulates contraction of the myoepithelial cells of the mammary acini producing milk let-down.
The uterine response can be modified by sexual hormones, being highly dependent on the presence of estrogens and progesterone.
When estrogen levels are low, the effect of oxytocin is much reduced
whereas when estrogen levels are high, such as during estrus, proestrus, and late pregnancy, the response
of the uterus to oxytocin is greatest.
On the other hand, progesterone antagonises the effect of oxytocin, so the excitation of smooth muscle decreases.
After parenteral administration, it is rapidly absorbed and it is partially bound by the plasma proteins.
It is metabolised in the body by oxytocin kinase.
Oxytocin half-life in plasma is short (2-3 minutes), and its rapid removal from the plasma is accomplished largely by the kidney and the liver where there is high oxytocin-inactivating activity.
Therefore, its effects disappear very quickly.
it excreted through the urine through a very small portion of oxytocin reaches the urine in active form.
It is also excreted via the mammary gland in lactating animals.
Target Species:
Horses, cattle, sheep, goats, cats, and dogs
Indications:
Obstetric use is (stimulation of uterine contraction to facilitate parturition in the presence of a fully dilated cervix, promotion of involution of the postpartum uterus, aid in the control of postpartum haemorrhage).
Promotion of milk let-down in cases of agalactia.
Administration and Dosage:
Provet Oxytocin is administered by subcutaneous, intramuscular or intravenous injection
Obstetric use :
Horse, cattle
7.5-10ml IM
0.25-10ml IV
Sheep, goat
3.5-5ML IM
0.05-0.25ML IV
DOG
0.5-2.5ML IM
0.5-0.05ML IV
CAT 0.5-1ML IM
For treatment of agalactia:
Horse, cattle 1-3 ml
Sheep, goat 0.5-2 ml
Dog, cat 0.1-1 ml
Special precautions for storage:
Keep the container in the outer carton.
Protect from light.
Store at room temperature at 25°C.
Warnings:
Keep out of the reach of children.
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